Liquid Nitrogen (Cryo) freezers are essential for preserving critical biological material. A Cryo freezer provides storage below Tg (glass transition temperature of water), reducing biological activity, and is the best method for stable and secure cell preservation. However, in some parts of the country, recent developments in the liquified atmospheric gas industry have created supply chain challenges that have called into question the reliable supply of cryogens, compromising this critical form of cell preservation.
CHALLENGES IN REGIONAL LN2 PRODUCTION PLANTS IMPACT BULK DELIVERY FOR CRYOGENIC FREEZERS.
COVID-19 factors have dramatically increased the demand for breathable oxygen in hospitals and other medical facilities. Because plants are making more oxygen, their production of LN2 has been significantly reduced. The gas companies are operating under force majeure and reducing customer LN2 allocations. As a result, it is impossible to quickly ramp up overall plant capacity to address this demand spike, coupled with reduced transport cylinder availability, trucks for distribution, and operations personnel. For many, the once-reliable LN2 supply chain is at a breaking point.
MVE FUSION – A STAND-ALONE CRYOGENIC FREEZER REQUIRING NO ONGOING LN2 SUPPLY.
Inspired by MVE’s 1500 series model, the MVE Fusion freezer was designed to improve security and performance in challenging environments like the ones we face today. Unlike standard Cryo freezers, the MVE Fusion does not require a continuous supply of LN2. Instead, a cryogen reservoir is mounted in the center of the freezer and attached to a cryocooler, which draws steady, low power for energy efficiency. This configuration allows the LN2 to recondense and resupply the freezer’s cryogen requirements. In addition, positioning the reservoir in the middle of the freezer allows its exterior to act as a heat exchange surface and emit ultra-low air.
Furthermore, the design of the reservoir handles pressure changes within the freezer during sample removal and the opening/closing of the lid. The ability to handle pressure changes by the reservoir allows for less leakage of LN2, which further minimizes the loss of LN2. Lastly, in the event of a power interruption, the abundant LN2 supply within the reservoir will allow for more than a week of hold time at constant temperatures below Tg.
The MVE Fusion technology presents an innovative opportunity for Life Science. With supply chain issues surrounding liquid nitrogen, the Fusion proves to be a practical self-sustaining solution to cryopreservation challenges. Not only does this highly efficient steel tank preserve LN2 optimally, but it also requires less maintenance downtime, is more energy-efficient, and is very reliable and secure.
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